Zeigler Z R
Department of Medicine, Montefiore Hospital, Pittsburgh, PA 15213.
Am J Hematol. 1989 Aug;31(4):248-52. doi: 10.1002/ajh.2830310406.
Seven patients with a suspected mild bleeding disorder had consistently abnormal glass bead platelet retention. This was the only coagulation abnormality detected in six of these patients; the seventh individual showed evidence of mild von Willebrand disease. Nevertheless, platelets from the six that were studied behaved in a similar fashion in the two-stage platelet retention assay of McPherson and Zucker. This indicated that their platelets were defective in maintaining repetitive platelet-platelet interaction in the second phase of this assay but functioned normally in the first phase. Their one-stage platelet retention defects consistently normalized following the infusion of 1-deamino-8-D-arginine-vasopressin (d-DAVP). The duration of response was variable and easily defined by monitoring this parameter. These findings suggest platelet retention analysis may be useful in identifying mild bleeding disorder patients, who may benefit from d-DAVP.
7名疑似患有轻度出血性疾病的患者，其玻璃珠血小板滞留试验结果始终异常。在其中6名患者中，这是唯一检测到的凝血异常；第7名患者显示有轻度血管性血友病的迹象。然而，在麦克弗森和祖克的两阶段血小板滞留试验中，接受研究的6名患者的血小板表现出相似的行为。这表明，在该试验的第二阶段，他们的血小板在维持重复性血小板-血小板相互作用方面存在缺陷，但在第一阶段功能正常。输注1-去氨基-8-D-精氨酸加压素（d-DAVP）后，他们的单阶段血小板滞留缺陷始终恢复正常。反应持续时间各不相同，通过监测该参数可轻松确定。这些发现表明，血小板滞留分析可能有助于识别可能从d-DAVP中获益的轻度出血性疾病患者。
