Ruma T A, Mintz P, Davey F R, Stuart M, Nelson D A
Ann Clin Lab Sci. 1979 Mar-Apr;9(2):173-8.
Platelet glass bead retention by the Salzman and infusion pump techniques were compared in 36 control individuals, 10 patients with von Willebrand's syndrome and four patients with thrombocytopathies. No significant differences between the results of the two assays were observed. Eleven percent or less of the control individuals had diminished platelet glass bead retention. The mean percentage platelet retention of the von Willebrand's group and the thrombocytopathy group was less than the mean platelet retention of the control group. However, at least 50 percent of the patients with von Willebrand's syndrome had normal platelet retention by both methods. In the thrombocytopathy group, glass bead retention was more consistently diminished. Although an inverse correlation existed between the duration of bleeding time and the platelet retention assays, consistently diminished platelet retention results were observed only when the bleeding time was 18 minutes or longer. It has been concluded by us that while the glass bead retention assays may be helpful in characterizing certain types of platelet disorders, they are not useful screening assays in the diagnosis of von Willebrand's syndrome.
在36名对照个体、10名血管性血友病患者和4名血小板病患者中，比较了采用萨尔兹曼法和输液泵技术测定的血小板玻璃珠滞留情况。两种检测结果之间未观察到显著差异。11%或更少的对照个体血小板玻璃珠滞留减少。血管性血友病组和血小板病组的血小板滞留平均百分比低于对照组的平均血小板滞留率。然而，至少50%的血管性血友病患者通过两种方法检测的血小板滞留情况正常。在血小板病组中，玻璃珠滞留更持续地减少。虽然出血时间与血小板滞留检测之间存在负相关，但仅当出血时间为18分钟或更长时，才观察到持续减少的血小板滞留结果。我们得出的结论是，虽然玻璃珠滞留检测可能有助于表征某些类型的血小板疾病，但它们在血管性血友病综合征的诊断中并非有用的筛查检测。
