精神分裂症患者血液中 MLL1 mRNA 和 BDNF 启动子 IV 上组蛋白 H3K4me3 水平升高。

Higher blood MLL1 mRNA and BDNF promoter IV on histone H3K4me3 levels in patients with schizophrenia.

机构信息

Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

出版信息

Psychiatry Res. 2016 Sep 30;243:207-9. doi: 10.1016/j.psychres.2016.06.010. Epub 2016 Jun 16.

DOI:10.1016/j.psychres.2016.06.010

PMID:27419650

Abstract

We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls. Over one year, 36 patients with schizophrenia and 32 controls were recruited. Psychiatric diagnoses were made based on DSM-IV criteria. Higher blood MLL1 mRNA and BDNF exon IV promoter on H3K4me3 levels were noted in patients with schizophrenia than in controls. The results showed that blood MLL1 mRNA and BDNF exon IV on H3K4me3 levels might be involved in the psychopathology of schizophrenia.

摘要

我们研究了精神分裂症患者和对照组外周血中混合谱系白血病 1 (MLL1) mRNA 和脑源性神经营养因子 (BDNF) 外显子 IV 启动子在组蛋白 H3K4 三甲基化 (H3K4me3) 上的水平。在一年多的时间里，共招募了 36 名精神分裂症患者和 32 名对照者。精神病诊断基于 DSM-IV 标准。与对照组相比，精神分裂症患者的外周血 MLL1 mRNA 和 BDNF 外显子 IV 启动子在 H3K4me3 上的水平更高。结果表明，血液 MLL1 mRNA 和 BDNF 外显子 IV 在 H3K4me3 上的水平可能与精神分裂症的精神病理学有关。