Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Genomic and Proteomic Core Laboratory, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Biomed J. 2020 Apr;43(2):134-142. doi: 10.1016/j.bj.2020.01.001. Epub 2020 May 5.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder.
脑源性神经营养因子（BDNF）是一种神经营养因子，可调节大脑中的神经可塑性，是精神疾病中研究最广泛的分子之一。BDNF 的研究涵盖了过去几十年研究技术的进步。BDNF 的研究范围从蛋白质定量、RNA 表达测量、DNA 测序，到最近但并非最不重要的表观遗传研究。在这篇综述中，我们将简要介绍精神分裂症、重度抑郁症（MDD）和双相情感障碍中 BDNF 蛋白水平、mRNA 表达、Val66Met 多态性和表观遗传修饰的研究结果。
