Destro-Bisol G, Spedini G
Department of Human and Animal Biology, University of Rome, La Sapienza, Italy.
Am J Phys Anthropol. 1989 Jun;79(2):217-24. doi: 10.1002/ajpa.1330790209.
Phenotype and allele frequencies for erythrocyte glutathione peroxidase (GPX1) polymorphism are reported in the Mbugu and Sango (Central African Republic), Goun (Benin), and Bamileke (Cameroon) ethnic groups. The GPX12 allele frequencies (from 0.012 in the Sango to 0.058 in the Bamileke) fit into the range of the data already known for the Subsaharan populations. The value of GPX12 for study of the genetic admixture between Negro and Pygmy populations is suggested. Three different unusual GPX1 electrotypes are described. Finally, we hypothesize an interaction between GPX12 and Hb betaS allelic products occurring in the sickle cells infected by Plasmodium falciparum.
报告了姆布古族和桑戈族（中非共和国）、古恩族（贝宁）以及巴米累克族（喀麦隆）红细胞谷胱甘肽过氧化物酶（GPX1）多态性的表型和等位基因频率。GPX12等位基因频率（从桑戈族的0.012到巴米累克族的0.058）符合撒哈拉以南人群已知数据的范围。提出了GPX12在研究黑人和俾格米人群体之间基因混合方面的价值。描述了三种不同的异常GPX1电泳类型。最后，我们推测在感染恶性疟原虫的镰状细胞中，GPX12和Hb betaS等位基因产物之间存在相互作用。
