一项关于喀麦隆异常血红蛋白分布的为期七年的人类生物学调查。

A seven year anthropobiological survey on the distribution of abnormal hemoglobins in Cameroon.

作者信息

Martorana M C, Battaggia C, Destro-Bisol G, Sansonetti B, Aebischer M L, Spedini G

机构信息

Department of Animal and Human Biology, University La Sapienza, Rome, Italy.

出版信息

Anthropol Anz. 1996 Sep;54(3):229-37.

PMID:8870947

Abstract

Within the frame of an anthropobiological survey on some populations of Cameroon (1985-1991), Hb beta data were collected from numerous ethnic groups including Bakaka, Bamileke, Daba, Fali, Guiziga, Kanuri, Mada, Mafa, Mundang, Uldeme, Podokwo, Tali, Tupuri, Fulbe, Mandara, Ewondo and Bassa. Hb beta *S allele frequencies ranged from 0.008 +/- 0.003 (among Fali) to 0.152 +/- 0.020 (among Mandara) and 0.152 +/- 0.044 (among Podokwo), whereas Hb beta *S was found to be absent among Tupuri. Hb beta *C was observed among Bamileke (0.001 +/- 0.001), Fali (0.003 +/- 0.002), Fulbe (0.002 +/- 0.002), Mafa (0.005 +/- 0.005), Mundang (0.005 +/- 0.005), Tupuri (0.010 +/- 0.007) and Podokwo (0.015 +/- 0.015). The possible reasons for these variations in allele frequencies are discussed.

摘要

在一项针对喀麦隆一些人群的人类生物学调查（1985 - 1991年）框架内，从包括巴卡卡、巴米累克、达巴、法利、吉齐加、卡努里、马达、马法、蒙当、乌尔德梅、波多科沃、塔利、图普里、富尔贝、曼达拉、埃翁多和巴萨等众多族群中收集了血红蛋白β数据。血红蛋白βS等位基因频率范围从0.008±0.003（法利人群中）到0.152±0.020（曼达拉人群中）以及0.152±0.044（波多科沃人群中），而在图普里人群中未发现血红蛋白βS。在巴米累克（0.001±0.001）、法利（0.003±0.002）、富尔贝（0.002±0.002）、马法（0.005±0.005）、蒙当（0.005±0.005）、图普里（0.010±0.007）和波多科沃（0.015±0.015）人群中观察到了血红蛋白β*C。文中讨论了这些等位基因频率变化的可能原因。