乳腺发育与乳腺癌：Wnt 视角。
Mammary Development and Breast Cancer: A Wnt Perspective.
机构信息
State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Department of Molecular Biology and Biochemistry, Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
出版信息
Cancers (Basel). 2016 Jul 13;8(7):65. doi: 10.3390/cancers8070065.
The Wnt pathway has emerged as a key signaling cascade participating in mammary organogenesis and breast oncogenesis. In this review, we will summarize the current knowledge of how the pathway regulates stem cells and normal development of the mammary gland, and discuss how its various components contribute to breast carcinoma pathology.
Wnt 通路已成为参与乳腺器官发生和乳腺癌发生的关键信号级联反应。在这篇综述中，我们将总结该通路如何调节干细胞和乳腺正常发育的现有知识，并讨论其各种成分如何促进乳腺癌的病理发生。
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