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乳腺中的Wnt信号传导：从发育到疾病

Wnt Signaling in the Breast: From Development to Disease.

作者信息

Abreu de Oliveira Willy Antoni, El Laithy Youssef, Bruna Alejandra, Annibali Daniela, Lluis Frederic

机构信息

Department of Development and Regeneration, Stem Cell Institute, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.

Centre for Paediatric Oncology Experimental Medicine, Centre for Cancer Evolution, Molecular Pathology Division, London, United Kingdom.

出版信息

Front Cell Dev Biol. 2022 May 18;10:884467. doi: 10.3389/fcell.2022.884467. eCollection 2022.

DOI:10.3389/fcell.2022.884467
PMID:35663403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9157790/
Abstract

The Wnt cascade is a primordial developmental signaling pathway that plays a myriad of essential functions throughout development and adult homeostasis in virtually all animal species. Aberrant Wnt activity is implicated in embryonic and tissue morphogenesis defects, and several diseases, most notably cancer. The role of Wnt signaling in mammary gland development and breast cancer initiation, maintenance, and progression is far from being completely understood and is rather shrouded in controversy. In this review, we dissect the fundamental role of Wnt signaling in mammary gland development and adult homeostasis and explore how defects in its tightly regulated and intricated molecular network are interlinked with cancer, with a focus on the breast.

摘要

Wnt信号通路是一条原始的发育信号通路，在几乎所有动物物种的整个发育过程和成年期稳态中发挥着无数重要功能。Wnt活性异常与胚胎和组织形态发生缺陷以及多种疾病有关，最显著的是癌症。Wnt信号在乳腺发育以及乳腺癌的起始、维持和进展中的作用远未被完全理解，而且相当具有争议性。在这篇综述中，我们剖析Wnt信号在乳腺发育和成年期稳态中的基本作用，并探讨其紧密调控且错综复杂的分子网络中的缺陷如何与癌症相互关联，重点关注乳腺癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/02816b91c424/fcell-10-884467-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/05db7ccf4f0e/fcell-10-884467-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/35265369f8e7/fcell-10-884467-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/7a942fae28ab/fcell-10-884467-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/56d224b3f1fa/fcell-10-884467-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/02816b91c424/fcell-10-884467-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/05db7ccf4f0e/fcell-10-884467-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/35265369f8e7/fcell-10-884467-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/7a942fae28ab/fcell-10-884467-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/56d224b3f1fa/fcell-10-884467-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c0/9157790/02816b91c424/fcell-10-884467-g005.jpg

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Advances in targeting the WNT/β-catenin signaling pathway in cancer.
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