Settepani Fabrizio, Cappai Antioco, Basciu Alessio, Barbone Alessandro, Moz Monica, Citterio Enrico, Ornaghi Diego, Tarelli Giuseppe
Department of Cardiac Surgery, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
Department of Cardiac Surgery, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
Ann Thorac Surg. 2016 Nov;102(5):1503-1511. doi: 10.1016/j.athoracsur.2016.04.061. Epub 2016 Jul 14.
We assessed whether additional cusp repair during valve-sparing aortic root replacement affects the echocardiographic mid-term results; a subgroup analysis among patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) was performed.
Between June 2002 and May 2015, 157 consecutive patients underwent valve-sparing aortic root replacement with the David technique. Thirty patients (19%) had BAV. In 19 patients (12%), cusp motion or anatomic abnormalities contributed in determining aortic regurgitation requiring an additional cusp repair. Mean follow-up was 7 ± 3.4 years.
The cumulative 1-, 5-, and 12-year survival rates were 98%, 94%, and 90%, respectively. Fourteen patients (9%) required aortic valve replacement during follow-up. In 2 patients the underlying cause was bacterial endocarditis. Freedom from aortic valve reoperation was 96% at 1 year, 92% at 5 years, and 89% at 12 years. Reoperation rate was significantly higher (p < 0.001) in patients who received leaflet repair compared with patients who did not, with a freedom from reoperation at 8 years of 58% versus 94%. Among patients with BAV, those who did not require cusp repair had a freedom from reoperation at 8 years of 94%, with a significant difference compared with patients who received cusp repair (p = 0.04). Cusp repair did not affect reoperation risk in patients with tricuspid aortic valve.
Adjunctive cusp repair seems to affect the mid-term reoperation risk in patients with BAV and not in patients with tricuspid aortic valve. We recommend caution in using this technique in case of asymmetric BAV requiring cusp repair.
我们评估了保留瓣膜主动脉根部置换术中额外的瓣叶修复是否会影响超声心动图中期结果;对二叶式主动脉瓣(BAV)和三叶式主动脉瓣(TAV)患者进行了亚组分析。
2002年6月至2015年5月期间,157例连续患者采用大卫技术进行了保留瓣膜主动脉根部置换术。30例患者(19%)患有BAV。19例患者(12%)的瓣叶运动或解剖异常导致了主动脉瓣反流,需要额外进行瓣叶修复。平均随访时间为7±3.4年。
1年、5年和12年的累积生存率分别为98%、94%和90%。14例患者(9%)在随访期间需要进行主动脉瓣置换。2例患者的根本原因是细菌性心内膜炎。主动脉瓣再次手术的免手术率在1年时为96%,5年时为92%,12年时为89%。接受瓣叶修复的患者再次手术率显著更高(p<0.001),8年时再次手术免手术率为58%,而未接受瓣叶修复的患者为94%。在BAV患者中,不需要瓣叶修复的患者8年时再次手术免手术率为94%,与接受瓣叶修复的患者相比有显著差异(p=0.04)。瓣叶修复对三叶式主动脉瓣患者的再次手术风险没有影响。
辅助瓣叶修复似乎会影响BAV患者的中期再次手术风险,而对三叶式主动脉瓣患者则无影响。对于需要瓣叶修复的不对称BAV患者,我们建议谨慎使用该技术。