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二叶式主动脉瓣行保留瓣膜根部的根部重植和瓣叶修复:与三尖瓣 David 手术的比较。

Valve-sparing root reimplantation and leaflet repair in a bicuspid aortic valve: comparison with the 3-cusp David procedure.

机构信息

University of Pennsylvania, Philadelphia, Pa.

University of Pennsylvania, Philadelphia, Pa.

出版信息

J Thorac Cardiovasc Surg. 2015 Feb;149(2 Suppl):S22-8. doi: 10.1016/j.jtcvs.2014.10.103. Epub 2014 Nov 1.

Abstract

OBJECTIVE

Valve-sparing root reimplantation (VSRR) in tricuspid aortic valve (TAV) patients is well established, but in bicuspid aortic valve (BAV) patients, it has been less widely adopted. We assessed whether valve type affects midterm outcomes with VSRR.

METHODS

A retrospective review was performed of 186 patients who underwent an aortic valve-sparing root reimplantation operation between 2004 and 2013. Of these, 129 patients underwent elective VSRR with the David V technique. Outcomes were compared in this cohort by valve type: TAV (n = 89) versus BAV (n = 40).

RESULTS

Demographics were similar in the 2 groups. BAV patients had a higher degree of aortic insufficiency (AI) at presentation (P < .05), and an enlarged preoperative annulus (30 ± 4 vs 28 ± 6 mm, P = .06). All BAV patients required primary leaflet repair (6% in the TAV group; P < .01). Postoperative mortality (0), stroke (0% vs 1%), and pacemaker requirement (0% vs 5%) were similar. Postoperative freedom from AI grade ≥2+ was 100% in the entire cohort, and transvalvular gradients were similar. At follow-up, a 1-year echocardiogram showed higher peak and mean transvalvular gradients in the BAV group (P < .01). One TAV group patient died from an unknown cause. The 5-year actuarial freedom from aortic valve reoperation was 100% versus 97% ± 3% (P = .6). Three patients in the entire cohort have had AI grade >2+ on follow-up (n = 1 in the BAV group; n = 2 in the TAV group).

CONCLUSIONS

Even though BAV patients present with higher AI grade and require concomitant primary valve repair, the VSRR David V technique offers excellent midterm outcomes with both the BAV and TAV valve types.

摘要

目的

在三尖瓣主动脉瓣(TAV)患者中,保留瓣膜的根部再植入术(VSRR)已得到广泛应用,但在二叶式主动脉瓣(BAV)患者中,其应用相对较少。我们评估了瓣膜类型是否会影响 VSRR 的中期结果。

方法

回顾性分析了 2004 年至 2013 年间接受主动脉瓣保留根部再植入术的 186 例患者。其中,129 例患者采用 David V 技术行择期 VSRR。通过瓣膜类型比较该队列的结果:TAV(n=89)与 BAV(n=40)。

结果

两组患者的人口统计学特征相似。BAV 患者术前主动脉瓣关闭不全(AI)程度更高(P<.05),术前瓣环较大(30±4 比 28±6mm,P=.06)。所有 BAV 患者均需行主瓣修复(TAV 组 6%;P<.01)。术后死亡率(0)、卒中和(0%比 1%)、起搏器需求(0%比 5%)相似。整个队列的术后 AI 分级≥2+的无复发率为 100%,跨瓣压差相似。随访 1 年的超声心动图显示,BAV 组的峰值和平均跨瓣压差较高(P<.01)。TAV 组有 1 例患者死于不明原因。5 年主动脉瓣再手术的累计生存率为 100%比 97%±3%(P=.6)。整个队列中有 3 例患者出现 AI 分级>2+(BAV 组 1 例,TAV 组 2 例)。

结论

尽管 BAV 患者 AI 分级较高,且需要同时行主瓣修复,但 VSRR David V 技术为 BAV 和 TAV 瓣膜类型提供了出色的中期结果。

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