Sakamoto Y, Kabe J, Horai Y
Department of Medicine and Physical Therapy, School of Medicine, University of Tokyo, Japan.
Ann Allergy. 1989 Jul;63(1):21-7.
The bronchodilating effect of theophylline was studied from the perspective of its influence on the severity of acute asthmatic attack and where its acting site is located on bronchi. Pulmonary function including maximal expiratory flow-volume curve breathing of room air and of a gas mixture containing 80% helium and 20% oxygen (He-O2) was measured at each incremental plasma theophylline concentration plateau (5, 10, and 15 micrograms/mL) in 12 acutely ill asthmatic patients. Before starting the administration of theophylline, clinical findings were used to classify the severity of the asthmatic attack into mild, moderate, or severe groups. Our data suggested that theophylline acts on both the central and peripheral airways and that theophylline improves the airway obstruction in a dose-dependent fashion when the severity of acute attack is mild.
从茶碱对急性哮喘发作严重程度的影响及其作用部位在支气管的何处这一角度，对其支气管扩张作用进行了研究。在12例急性哮喘患者中，于血浆茶碱浓度的每个递增稳定期（5、10和15微克/毫升）测量肺功能，包括吸入室内空气以及含80%氦气和20%氧气的混合气体（氦氧混合气）时的最大呼气流量-容积曲线。在开始给予茶碱之前，根据临床症状将哮喘发作的严重程度分为轻度、中度或重度组。我们的数据表明，茶碱作用于中央气道和外周气道，并且当急性发作程度为轻度时，茶碱以剂量依赖方式改善气道阻塞。
