Mak H, Chipps B E, Menkes H A, Schuberth K C, Talamo J H, Scherr M S, Talamo R C, Permutt S
Br J Dis Chest. 1982 Jan;76(1):51-6.
In order to assess diurnal variation of flow-volume curves and to determine whether small airways are involved in the diurnal variation of pulmonary function in asthmatic children, we studied eight asthmatics who were attending an asthma summer camp. Spirometry and maximal expiratory flow-volume curves with air and a helium-oxygen mixture were obtained in the morning and afternoon over a 10-day period. We found that significant increases in maximal expiratory flows at all lung volumes occurred in the afternoon. However, the increase in flows with helium (helium response) was unchanged from morning to afternoon. These results suggest that both large and small airways are involved in the diurnal variation of pulmonary function in asthmatic children.
为了评估流量-容积曲线的昼夜变化，并确定小气道是否参与哮喘儿童肺功能的昼夜变化，我们研究了八名参加哮喘夏令营的哮喘患者。在10天的时间里，于上午和下午分别进行了肺活量测定以及空气和氦氧混合气的最大呼气流量-容积曲线测定。我们发现，下午所有肺容积下的最大呼气流量均显著增加。然而，氦气情况下的流量增加（氦气反应）从上午到下午没有变化。这些结果表明，大气道和小气道均参与哮喘儿童肺功能的昼夜变化。
