Bhushan Sudhanshu, Meinhardt Andreas
Department of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Germany.
Department of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Germany.
J Reprod Immunol. 2017 Feb;119:107-112. doi: 10.1016/j.jri.2016.06.008. Epub 2016 Jun 30.
Testicular macrophages are the largest leukocyte population in the testis. Their environment is characterized by the seemingly contradictory needs for tolerance against the autoantigenic germ cells and the capacity to mount pro-inflammatory innate immune responses against invading pathogens. During the past years considerable progress has been made in our understanding how intracellular signaling events enable testicular macrophages to adequately respond to inflammatory stimuli with the capacity to clear pathogens, but avoid excessive tissue damage to maintain fertility. Moreover, new data add to our understanding that testicular macrophages play essential roles in normal testis homeostasis and fetal testicular development.
睾丸巨噬细胞是睾丸中数量最多的白细胞群体。它们所处的环境具有看似相互矛盾的需求，既要对自身抗原性生殖细胞具有耐受性，又要具备针对入侵病原体引发促炎性固有免疫反应的能力。在过去几年里，我们在理解细胞内信号事件如何使睾丸巨噬细胞能够充分响应炎症刺激以清除病原体、同时避免过度组织损伤以维持生育能力方面取得了相当大的进展。此外，新的数据增进了我们对睾丸巨噬细胞在正常睾丸内环境稳定和胎儿睾丸发育中发挥重要作用的理解。
