Torriglia Alicia, Martin Elisabeth, Jaadane Imene
INSERM U1138, Centre de Recherches des Cordeliers, Université Paris Descartes, Université Pierre et Marie Curie, Paris, France.
INSERM U1138, Centre de Recherches des Cordeliers, Université Paris Descartes, Université Pierre et Marie Curie, Paris, France.
Semin Cell Dev Biol. 2017 Feb;62:178-186. doi: 10.1016/j.semcdb.2016.07.010. Epub 2016 Jul 12.
SERPINB1, also called Leukocyte Elastase Inhibitor (LEI) is a member of the clade B of SERPINS. It is an intracellular protein and acts primarily to protect the cell from proteases released into the cytoplasm during stress. Its role in inflammation is clear due to its involvement in the resolution of chronic inflammatory lung and bowel diseases. LEI/SERPINB1 intrinsically possesses two enzymatic activities: an antiprotease activity dependent on its reactive site loop, which is analogous to the other proteins of the family and an endonuclease activity which is unveiled by the cleavage of the reactive site loop. The conformational change induced by this cleavage also unveils a bipartite nuclear localization signal allowing the protein to translocate to the nucleus. Recent data indicate that it has also a role in cell migration suggesting that it could be involved in diverse processes like wound healing and malignant metastases.
丝氨酸蛋白酶抑制剂B1（SERPINB1），也称为白细胞弹性蛋白酶抑制剂（LEI），是丝氨酸蛋白酶抑制剂B家族的成员。它是一种细胞内蛋白质，主要作用是在应激期间保护细胞免受释放到细胞质中的蛋白酶的侵害。由于它参与慢性炎症性肺和肠道疾病的消退，其在炎症中的作用是明确的。LEI/SERPINB1本质上具有两种酶活性：一种依赖于其反应位点环的抗蛋白酶活性，这与该家族的其他蛋白质类似；另一种是通过反应位点环的切割而暴露的核酸内切酶活性。这种切割诱导的构象变化还揭示了一个双功能核定位信号，使该蛋白质能够转运到细胞核。最近的数据表明，它在细胞迁移中也起作用，这表明它可能参与诸如伤口愈合和恶性转移等多种过程。
