左旋葡聚糖酮及其相关衍生物对人肝癌细胞系的细胞毒性作用。
Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines.
作者信息
Giri Germán F, Danielli Mauro, Marinelli Raúl A, Spanevello Rolando A
机构信息
Instituto de Química de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario-CONICET, Suipacha 531, S2002LRK Rosario, Argentina.
Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario-CONICET, Suipacha 531, S2002LRK Rosario, Argentina.
出版信息
Bioorg Med Chem Lett. 2016 Aug 15;26(16):3955-7. doi: 10.1016/j.bmcl.2016.07.007. Epub 2016 Jul 4.
Levoglucosenone has been used as template for the synthesis of a wide variety of compounds with an impressive structural variability. However, scarce work has been done regarding the generation of new bioactive entities. Here we report the cytotoxic effect of levoglucosenone and some related derivatives against hepatocarcinoma cell lines. Compounds were obtained in only one synthetic step and one of them showed an activity within the range of IC50 values of cisplatin, a frequently administered chemotherapy drug.
左旋葡聚糖酮已被用作合成多种具有显著结构多样性的化合物的模板。然而，关于生成新的生物活性实体的研究却很少。在此，我们报告了左旋葡聚糖酮及其一些相关衍生物对肝癌细胞系的细胞毒性作用。这些化合物仅通过一步合成即可获得，其中一种化合物的活性在常用化疗药物顺铂的IC50值范围内。
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