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左旋葡萄糖酮：用于药物发现的生物基平台。

Levoglucosenone: Bio-Based Platform for Drug Discovery.

作者信息

Camp Jason E, Greatrex Ben W

机构信息

Circa Sustainable Chemicals, York, United Kingdom.

School of Science and Technology, University of New England, Armidale, NSW, Australia.

出版信息

Front Chem. 2022 May 31;10:902239. doi: 10.3389/fchem.2022.902239. eCollection 2022.

DOI:10.3389/fchem.2022.902239
PMID:35711952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9194561/
Abstract

Levoglucosone (LGO) is a bio-privileged molecule that can be produced on scale from waste biomass. This chiral building block has been converted via well-established chemical processes into previously difficult-to-synthesize building blocks such as enantiopure butenolides, dihydropyrans, substituted cyclopropanes, deoxy-sugars and ribonolactones. LGO is an excellent starting material for the synthesis of biologically active compounds, including those which have anti-cancer, anti-microbial or anti-inflammatory activity. This review will cover the conversion of LGO to biologically active compounds as well as provide future research directions related to this platform molecule.

摘要

左旋葡聚糖酮（LGO）是一种具有生物优势的分子，可以从废弃生物质大规模生产。这种手性砌块已通过成熟的化学过程转化为以前难以合成的砌块，如对映体纯的丁烯内酯、二氢吡喃、取代环丙烷、脱氧糖和核糖内酯。LGO是合成生物活性化合物的优良起始原料，包括那些具有抗癌、抗菌或抗炎活性的化合物。本综述将涵盖LGO向生物活性化合物的转化，并提供与该平台分子相关的未来研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a9/9194561/11e3db1f822c/fchem-10-902239-g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a9/9194561/54f26a450f45/fchem-10-902239-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a9/9194561/d6d58c41c784/fchem-10-902239-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a9/9194561/c24e7388e276/fchem-10-902239-g003.jpg
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