Couderc Jean-Philippe, Beshaw Connor, Niu Xiaodan, Serrano-Finetti Ernesto, Casas Oscar, Pallas-Areny Ramon, Rosero Spencer, Zareba Wojciech
Heart Research Follow-Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, NY, USA.
Universitat Politècnica de Catalunya, BarcelonaTech, Barcelona, Spain.
Ann Noninvasive Electrocardiol. 2017 Jan;22(1). doi: 10.1111/anec.12378. Epub 2016 Jul 15.
Despite the strong evidence of the clinical utility of QTc prolongation as a surrogate marker of cardiac risk, QTc measurement is not part of clinical routine either in hospital or in physician offices. We evaluated a novel device ("the QT scale") to measure heart rate (HR) and QTc interval.
The QT scale is a weight scale embedding an ECG acquisition system with four limb sensors (feet and hands: lead I, II, and III). We evaluated the reliability of QT scale in healthy subjects (cohort 1) and cardiac patients (cohorts 2 and 3) considering a learning (cohort 2) and two validation cohorts. The QT scale and the standard 12-lead recorder were compared using intraclass correlation coefficient (ICC) in cohorts 2 and 3. Absolute value of heart rate and QTc intervals between manual and automatic measurements using ECGs from the QT scale and a clinical device were compared in cohort 1.
We enrolled 16 subjects in cohort 1 (8 w, 8 m; 32 ± 8 vs 34 ± 10 years, P = 0.7), 51 patients in cohort 2 (13 w, 38 m; 61 ± 16 vs 58 ± 18 years, P = 0.6), and 13 AF patients in cohort 3 (4 w, 9 m; 63 ± 10 vs 64 ± 10 years, P = 0.9). Similar automatic heart rate and QTc were delivered by the scale and the clinical device in cohort 1: paired difference in RR and QTc were -7 ± 34 milliseconds (P = 0.37) and 3.4 ± 28.6 milliseconds (P = 0.64), respectively. The measurement of stability was slightly lower in ECG from the QT scale than from the clinical device (ICC: 91% vs 80%) in cohort 3.
The "QT scale device" delivers valid heart rate and QTc interval measurements.
尽管有充分证据表明QTc延长作为心脏风险替代标志物具有临床实用性，但QTc测量在医院或医生办公室的临床常规工作中都不是一部分。我们评估了一种新型设备（“QT量表”）来测量心率（HR）和QTc间期。
QT量表是一种体重秤，内置一个带有四个肢体传感器（双脚和双手：I、II和III导联）的心电图采集系统。我们在健康受试者（队列1）和心脏病患者（队列2和3）中评估了QT量表的可靠性，其中队列2为学习阶段，队列3为两个验证队列。在队列2和3中，使用组内相关系数（ICC）比较QT量表和标准12导联记录仪。在队列1中，比较使用QT量表心电图和临床设备进行手动和自动测量时心率和QTc间期的绝对值。
我们纳入了队列1中的16名受试者（8名女性，8名男性；年龄分别为32±8岁和34±10岁，P = 0.7），队列2中的51名患者（13名女性，38名男性；年龄分别为61±16岁和58±18岁，P = 0.6），以及队列3中的13名房颤患者（4名女性，9名男性；年龄分别为63±10岁和64±10岁，P = 0.9）。在队列1中，量表和临床设备得出的自动心率和QTc相似：RR和QTc的配对差异分别为-7±34毫秒（P = 0.37）和3.4±28.6毫秒（P = 0.64）。在队列3中，QT量表心电图的稳定性测量略低于临床设备（ICC：91%对80%）。
“QT量表设备”可提供有效的心率和QTc间期测量。
