Gariepy Aileen M, Lundsberg Lisbet S, Miller Devin, Stanwood Nancy L, Yonkers Kimberly A
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, United States.
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, United States.
J Affect Disord. 2016 Nov 15;205:87-94. doi: 10.1016/j.jad.2016.06.058. Epub 2016 Jun 27.
Pregnancy planning and timing may be associated with psychiatric illness, psychological distress and support during pregnancy.
We performed secondary analyses of a prospective cohort of 2654 pregnant women evaluating the impact of depression on preterm birth. We used multivariable logistic regression to test associations between pregnancy planning ("Was this pregnancy planned? Yes/No") and/or timing ("Do you think this is a good time for you to be pregnant?") with Composite International Diagnostic Interview generated psychiatric diagnoses and measures of psychological distress and support.
37% and 13% of participants reported an unplanned or poorly timed pregnancy, respectively. Unplanned pregnancies were associated with a Major Depressive Episode (MDE) (adjusted odds ratio (aOR) 1.69, 95%CI 1.23-2.32) and the Cohen Perceived Stress Scale's (CPSS) highest quartile (aOR 1.74, 95%CI 1.40-2.16). Poorly timed pregnancies were associated with a MDE (aOR 3.47, 95%CI 2.46-4.91) and the CPSS's highest quartile (aOR 5.20, 95%CI 3.93-6.87). Poorly timed pregnancies were also associated with General Anxiety Disorder (GAD; aOR 1.60, 95%CI 1.07-2.40), and the modified Kendler Social Support Inventory's (MKSSI) lowest quartile (aOR 1.64, 95%CI 1.25-2.16). Psychiatric conditions were strongly associated with planned pregnancies that were subsequently deemed poorly timed (MDE=aOR 5.08, 95%CI 2.52-10.25; GAD=aOR 2.28, 95%CI 1.04-5.03); high CPSS=aOR 6.48, 95%CI 3.59-11.69; and low MKSSI=aOR 3.19, 95%CI 1.81-5.62.
Participant characteristics may limit generalizability of findings.
Pregnancy timing was a stronger predictor of maternal psychiatric illness, psychological distress and low social support than pregnancy planning in our cohort.
妊娠计划和时机可能与精神疾病、心理困扰以及孕期支持相关。
我们对2654名孕妇的前瞻性队列进行了二次分析,以评估抑郁症对早产的影响。我们使用多变量逻辑回归来检验妊娠计划(“此次妊娠是计划内的吗?是/否”)和/或时机(“你认为这是你怀孕的好时机吗?”)与综合国际诊断访谈得出的精神疾病诊断以及心理困扰和支持措施之间的关联。
分别有37%和13%的参与者报告此次妊娠为意外妊娠或时机不佳。意外妊娠与重度抑郁发作(MDE)相关(调整后的优势比[aOR]为1.69,95%置信区间[CI]为1.23 - 2.32)以及科恩感知压力量表(CPSS)的最高四分位数相关(aOR为1.74,95%CI为1.40 - 2.16)。时机不佳的妊娠与MDE相关(aOR为3.47,95%CI为2.46 - 4.91)以及CPSS的最高四分位数相关(aOR为5.20,95%CI为3.93 - 6.87)。时机不佳的妊娠还与广泛性焦虑障碍(GAD;aOR为1.60,95%CI为1.07 - 2.40)以及改良的肯德勒社会支持量表(MKSSI)的最低四分位数相关(aOR为1.64,95%CI为1.25 - 2.16)。精神疾病与随后被认为时机不佳的计划内妊娠密切相关(MDE:aOR为5.08,95%CI为2.52 - 10.25;GAD:aOR为2.28,95%CI为1.04 - 5.03;高CPSS:aOR为6.48,95%CI为3.59 - 11.69;低MKSSI:aOR为3.19,95%CI为1.81 - 5.62)。
参与者特征可能会限制研究结果的普遍性。
在我们的队列中,妊娠时机比妊娠计划更能预测母亲的精神疾病、心理困扰和低社会支持。