脑脊髓液 sTREM2 水平与早期阿尔茨海默病的灰质体积增加和弥散度降低有关。
Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease.
机构信息
Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain; Pompeu Fabra University, Barcelona, Spain.
BioMedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
出版信息
Alzheimers Dement. 2016 Dec;12(12):1259-1272. doi: 10.1016/j.jalz.2016.06.005. Epub 2016 Jul 14.
INTRODUCTION
TREM2 is involved in the regulation of inflammatory response and phagocytosis. A soluble fragment (sTREM2) is often found abnormally increased in cerebrospinal fluid (CSF) in Alzheimer's disease (AD).
METHODS
One hundred fourteen participants (45 control, 19 preclinical, 27 mild cognitive impairment [MCI], and 23 AD) underwent CSF sTREM2 determination and magnetic resonance imaging (MRI). We studied the association between CSF sTREM2, gray matter volume, and water motion diffusivity and anisotropy across groups.
RESULTS
In MCI patients, a positive correlation between CSF sTREM2 and gray matter volume was found in the bilateral inferior and middle temporal cortices, precuneus, the supramarginal, and angular gyri, after controlling by age, sex, and p-tau. A negative correlation with mean diffusivity was detected in overlapping regions, among others.
DISCUSSION
In early AD, augmented CSF sTREM2 levels correspond with cerebral MRI features typical of brain swelling, supporting a role for TREM2 in the regulation of the neuroinflammatory response to early neurodegeneration.
简介
TREM2 参与炎症反应和吞噬作用的调节。可溶性片段（sTREM2）在阿尔茨海默病（AD）患者的脑脊液（CSF）中常异常升高。
方法
114 名参与者（45 名对照组、19 名临床前组、27 名轻度认知障碍[MCI]组和 23 名 AD 组）接受 CSF sTREM2 测定和磁共振成像（MRI）。我们研究了 CSF sTREM2 与灰质体积以及水运动弥散率和各向异性之间的相关性在各组之间的关系。
结果
在 MCI 患者中，控制年龄、性别和 p-tau 后，CSF sTREM2 与双侧颞中下部、楔前叶、缘上回和角回的灰质体积呈正相关。在重叠区域中还检测到与平均弥散率呈负相关。
讨论
在早期 AD 中，增加的 CSF sTREM2 水平与脑肿胀的 MRI 特征相对应，支持 TREM2 在调节早期神经退行性变的神经炎症反应中的作用。
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