Xiaowei Xu, Department of Neurology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China; E-mail:
J Prev Alzheimers Dis. 2024;11(4):1087-1092. doi: 10.14283/jpad.2024.70.
Previous studies demonstrated a significant protective effect of elevated cerebrospinal fluid (CSF) sTREM2 levels on brain structure and cognitive decline. Nonetheless, the role of sTREM2 in the depression progression remains unclear. This study aimed to investigate the association between CSF sTREM2 levels and longitudinal trajectories of depression.
Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) Study were used. CSF sTREM2 levels and depression were measured using an ELISA-based assay and the Geriatric Depression Scale (GDS-15), respectively. Linear mixed-effect models were employed to assess the relationships between CSF sTREM2 levels and GDS scores.
A total of 1,017 participants were enrolled at baseline, with a mean follow-up time of 4.65 years. Baseline CSF sTREM2 levels were negatively correlated with GDS scores (β=-0.21, P=0.022) after adjustment for age, gender, race/ethnicity, education, APOE ε4 carrier status, TREM2 rare variant carrier status, marital status, smoking, and clinical cognitive status.
Our findings suggested that a higher level of CSF sTREM2 was associated with a lower risk of depression.
先前的研究表明，脑脊液 (CSF) sTREM2 水平升高对脑结构和认知能力下降具有显著的保护作用。然而，sTREM2 在抑郁症进展中的作用尚不清楚。本研究旨在探讨 CSF sTREM2 水平与抑郁症纵向轨迹之间的关系。
使用阿尔茨海默病神经影像学倡议 (ADNI) 研究的数据。使用基于 ELISA 的测定法和老年抑郁量表 (GDS-15) 分别测量 CSF sTREM2 水平和抑郁。线性混合效应模型用于评估 CSF sTREM2 水平与 GDS 评分之间的关系。
共有 1017 名参与者在基线时入组，平均随访时间为 4.65 年。调整年龄、性别、种族/民族、教育程度、APOE ε4 携带状态、TREM2 稀有变异携带者状态、婚姻状况、吸烟和临床认知状态后，基线 CSF sTREM2 水平与 GDS 评分呈负相关（β=-0.21，P=0.022）。
我们的研究结果表明，较高水平的 CSF sTREM2 与较低的抑郁风险相关。
