脂质在免疫细胞代谢和激活中的作用。
Role of lipids in the metabolism and activation of immune cells.
作者信息
Hubler Merla J, Kennedy Arion J
机构信息
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.
出版信息
J Nutr Biochem. 2016 Aug;34:1-7. doi: 10.1016/j.jnutbio.2015.11.002. Epub 2015 Nov 24.
Abstract
Immune cell plasticity has extensive implications in the pathogenesis and resolution of metabolic disorders, cancers, autoimmune diseases and chronic inflammatory disorders. Over the past decade, nutritional status has been discovered to influence the immune response. In metabolic disorders such as obesity, immune cells interact with various classes of lipids, which are capable of controlling the plasticity of macrophages and T lymphocytes. The purpose of this review is to discuss lipids and their impact on innate and adaptive immune responses, focusing on two areas: (1) the impact of altering lipid metabolism on immune cell activation, differentiation and function and (2) the mechanism by which lipids such as cholesterol and fatty acids regulate immune cell plasticity.
摘要
免疫细胞可塑性在代谢紊乱、癌症、自身免疫性疾病和慢性炎症性疾病的发病机制及转归中具有广泛影响。在过去十年中，人们发现营养状况会影响免疫反应。在肥胖等代谢紊乱中，免疫细胞与各类脂质相互作用，这些脂质能够控制巨噬细胞和T淋巴细胞的可塑性。本综述的目的是讨论脂质及其对固有免疫和适应性免疫反应的影响，重点关注两个方面：（1）脂质代谢改变对免疫细胞激活、分化和功能的影响；（2）胆固醇和脂肪酸等脂质调节免疫细胞可塑性的机制。
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本文引用的文献
1
IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17-Triggering Cytokine Production and Limiting Th17 Cell Proliferation.
J Immunol. 2015 Jun 1;194(11):5110-9. doi: 10.4049/jimmunol.1401810. Epub 2015 Apr 27.
2
Salicylate improves macrophage cholesterol homeostasis via activation of Ampk.
J Lipid Res. 2015 May;56(5):1025-33. doi: 10.1194/jlr.M058875. Epub 2015 Mar 15.
3
Fatty acids, lipid mediators, and T-cell function.
Front Immunol. 2014 Oct 13;5:483. doi: 10.3389/fimmu.2014.00483. eCollection 2014.
4
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.
Nat Med. 2014 Nov;20(11):1327-33. doi: 10.1038/nm.3704. Epub 2014 Oct 5.
5
Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice.
J Hepatol. 2015 Feb;62(2):430-6. doi: 10.1016/j.jhep.2014.09.027. Epub 2014 Oct 2.
6
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.
Cell Metab. 2014 Oct 7;20(4):614-25. doi: 10.1016/j.cmet.2014.08.010. Epub 2014 Sep 18.
7
Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.
Gynecol Oncol. 2014 Nov;135(2):333-41. doi: 10.1016/j.ygyno.2014.08.015. Epub 2014 Aug 16.
8
Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12163-8. doi: 10.1073/pnas.1322807111. Epub 2014 Aug 4.
9
The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.
Cell Metab. 2014 Jul 1;20(1):172-82. doi: 10.1016/j.cmet.2014.05.013. Epub 2014 Jun 19.
10
Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway.
Mucosal Immunol. 2015 Jan;8(1):80-93. doi: 10.1038/mi.2014.44. Epub 2014 Jun 11.
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