Edelman R
Prog Clin Biol Res. 1981;67:327-37.
Obesity, high-fat diets, or excess lipids interact with infectious agents and immunocompetent cells in the following ways: Some infections and autoimmune diseases are enhanced in inbred mice. In man, surgical wound infections are increased; the risk of tubercular death is decreased; no data exist on the interaction of lipids and autoimmune disease. Certain fatty acids and cholesterol are potent modulators of T lymphocyte and phagocyte functions in laboratory animals and in leukocyte cultures. However, in humans, the modulation of immune function by dietary lipids is still uncertain. Precisely how lipids interact with the immune system opens an important and exciting area for future research.
肥胖、高脂饮食或脂质过多通过以下方式与感染因子和免疫活性细胞相互作用：某些感染和自身免疫性疾病在近交系小鼠中会增强。在人类中，手术伤口感染会增加；结核病死亡风险会降低；目前尚无关于脂质与自身免疫性疾病相互作用的数据。某些脂肪酸和胆固醇在实验动物和白细胞培养物中是T淋巴细胞和吞噬细胞功能的有效调节剂。然而，在人类中，饮食脂质对免疫功能的调节仍不确定。脂质与免疫系统的确切相互作用为未来研究开辟了一个重要且令人兴奋的领域。
