Mattingly Jonathan R, Wu Aimee, York Autumn G
Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98195, USA.
Immune Netw. 2025 Feb 18;25(1):e11. doi: 10.4110/in.2025.25.e11. eCollection 2025 Feb.
The burgeoning field of immunometabolism highlights the interdependence between metabolic programs and efficacious immune responses. The current understanding that cellular metabolic remodeling is necessary for a competent adaptive immune response, along with acutely sensitive methodologies such as high-performance liquid chromatography/mass spectrometry and advanced proteomics, have ushered in a renaissance of lipid- and metabolic-based scientific inquiries. One facet of recent interest examines how lipids function as post-translational modifications (PTMs) and their resulting effects on adaptive immune responses. The goal of this review is to establish a fundamental understanding of these protein modifications and highlight recent findings that underscore the importance of continued investigation into lipids as PTMs.
免疫代谢这一新兴领域凸显了代谢程序与有效免疫反应之间的相互依存关系。目前的认识是，细胞代谢重塑对于有效的适应性免疫反应是必要的，再加上诸如高效液相色谱/质谱和先进蛋白质组学等极其灵敏的方法，引发了基于脂质和代谢的科学探究的复兴。近期研究的一个方面探讨了脂质如何作为翻译后修饰（PTM）发挥作用及其对适应性免疫反应的影响。本综述的目的是建立对这些蛋白质修饰的基本理解，并强调近期的研究结果，这些结果突显了持续研究脂质作为翻译后修饰的重要性。
