Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea; College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
Biomed Pharmacother. 2016 Oct;83:431-438. doi: 10.1016/j.biopha.2016.07.006. Epub 2016 Jul 15.
Type 2 diabetes mellitus (T2DM) is a metabolic syndrome that results from target-tissue resistance to insulin. Obesity is the condition of excess body fat accumulation. T2DM and obesity are both associated with hypertension, hyperlipidemia, and abdominal obesity. In Korean medicine, Yangkyuksanhwa-tang (YKSHT) has been prescribed for patients with T2DM. Oral glucose tolerance tests (OGTT), multiplex assays and hemoglobin A (HbA1C) assessments were performed to determine the anti-diabetic effects of YKSHT and two major compositions of YKSHT, Lonicera japonica Thunb. (LJT) and Rehmannia glutinosa (RG) on db/db mice, a rodent model for T2DM. To study the anti-obesitic effects of LJT, RG or YKSHT, blood profiling including the triglycerides (TGs) and the total, LDL and HDL cholesterol levels were measured. In addition, body index measures such as the liver, retroperitoneal and epididymal fat tissues were collected and weighed. Mice treated with RG or YKSHT showed reduced blood glucose levels after stimulating the plasma GLP-1 levels. The multiplex assay results support the weight-controlling effects of the LJT, RG and YKSHT treatments, showing reducing levels of ghrelin and the induction of peptide YY (PYY) secretion. The YKSHT treatment reduced plasma TG levels and increased HDL cholesterol levels. The weights of the liver, retroperitoneal and epididymal fat tissues were reduced after the YKSHT treatment. Hence, we suggest that YKSHT can be utilized for the prevention and treatment of T2DM and obesity simultaneously.
2 型糖尿病（T2DM）是一种代谢综合征，源于胰岛素靶组织抵抗。肥胖是指身体脂肪过度积累的状态。T2DM 和肥胖均与高血压、高血脂和腹部肥胖有关。在韩国医学中，Yangkyuksanhwa-tang（YKSHT）已被用于治疗 T2DM 患者。进行口服葡萄糖耐量试验（OGTT）、多重分析和血红蛋白 A（HbA1C）评估，以确定 YKSHT 及其两种主要成分金银花（LJT）和地黄（RG）对 db/db 小鼠的抗糖尿病作用，db/db 小鼠是 T2DM 的啮齿动物模型。为研究 LJT、RG 或 YKSHT 的抗肥胖作用，测量了包括甘油三酯（TGs）和总胆固醇、LDL 和 HDL 胆固醇水平在内的血液分析结果。此外，还收集并称重了身体指数指标，如肝脏、腹膜后和附睾脂肪组织。用 RG 或 YKSHT 治疗的小鼠在刺激血浆 GLP-1 水平后血糖水平降低。多重分析结果支持 LJT、RG 和 YKSHT 治疗的体重控制作用，显示出降低 ghrelin 水平和诱导肽 YY（PYY）分泌的作用。YKSHT 治疗降低了血浆 TG 水平并增加了 HDL 胆固醇水平。YKSHT 治疗后肝脏、腹膜后和附睾脂肪组织的重量减轻。因此，我们认为 YKSHT 可用于预防和治疗 T2DM 和肥胖症。
