Viassolo Valeria, Chappuis Pierre O
Rev Med Suisse. 2016 May 18;12(519):966, 968-72.
Approximately 5 to 10% of all malignant tumors can be attributed to highly penetrant cancer predisposition genes. More than 100 of these genes have been identified. Taking into account the complexity and the various implications of predictive oncology, and in accordance with the current regulation, every constitutional molecular analysis must be performed within the framework of a genetic counseling. Besides the implementation of the next generation sequencing technology in clinical laboratory, family history remains a key information to identify hereditary cancer syndromes and to propose genetic counseling. New challenge areas for clinicians involved in predictive oncology are also associated with this technical revolution.
所有恶性肿瘤中约5%至10%可归因于高外显率的癌症易感基因。目前已鉴定出100多种此类基因。考虑到预测性肿瘤学的复杂性和各种影响，并根据现行规定，每次体质分子分析都必须在遗传咨询的框架内进行。除了在临床实验室应用下一代测序技术外，家族史仍然是识别遗传性癌症综合征和提供遗传咨询的关键信息。参与预测性肿瘤学的临床医生面临的新挑战领域也与这一技术革命相关。
