Álvarez-Silvares E, Vilouta-Romero M, Borrajo-Hernández E, Morales-Serrano M L, Alves-Pérez M T
Ginecol Obstet Mex. 2016 Mar;84(3):150-63.
Some disorders of pregnancy and newborn have been associated with vitamin D deficiency (25 (OH) D) in maternal serum. The pathophysiology of this relationship is unknown today.
The aim of this study was to determine whether serum levels of vitamin D at the beginning of pregnancy are associated with gestational diabetes, hypertensive disorders of pregnancy, preterm birth and fetal growth restriction.
We conducted a prospective cohort study in 370 pregnant women at low obstetric risk randomly selected in our area (latitude 42 ° 20'N). The level of 25-hydroxy vitamin D was determinate between 8 and 14 weeks of pregnancy. We studied the relationship between the status of vitamin D and gestational diabetes, preeclampsia, preterm birth, intrauterine growth restriction and small for gestational age. The statistic analysis was performed using SPSS 15.0 and 3.1 Epidat programs.
The prevalence of vitamin D deficiency in pregnant women in this serie was 96.8%, 34.6% had severe deficiency. After adjusting for maternal and seasonal variables, we haven't found association between first trimester maternal serum vitamin D levels and pregnancy outcomes studied.
The pregnancy outcome was independent of the first trimester maternal serum 25(OH)D status.
妊娠和新生儿的一些疾病与母体血清维生素D缺乏（25（OH）D）有关。目前尚不清楚这种关系的病理生理学。
本研究旨在确定妊娠初期血清维生素D水平是否与妊娠期糖尿病、妊娠高血压疾病、早产和胎儿生长受限有关。
我们对在本地区（北纬42°20′）随机选取的370名低产科风险孕妇进行了一项前瞻性队列研究。在妊娠8至14周期间测定25-羟维生素D水平。我们研究了维生素D状态与妊娠期糖尿病、先兆子痫、早产、宫内生长受限和小于胎龄之间的关系。使用SPSS 15.0和3.1 Epidat程序进行统计分析。
本系列研究中孕妇维生素D缺乏的患病率为96.8%，34.6%为严重缺乏。在对母体和季节变量进行校正后，我们未发现妊娠早期母体血清维生素D水平与所研究的妊娠结局之间存在关联。
妊娠结局与妊娠早期母体血清25（OH）D状态无关。
