Solidoro Paolo, Bellocchia Michela, Facchini Fabrizio
Pulmonary Medicine Unit, Department of Cardiovascular and Thoracic Surgery, Città della Salute e della Scienza University Hospital, University of Turin, Turin, Italy -
Minerva Med. 2016 Jun;107(3 Suppl 1):12-9.
Vitamin D is a fat-soluble vitamin, which is obtained by conversion of 7-dehydrocholesterol in the skin by UV ray and by diet. Its role on bone mineralization has been known for over two hundred years, while its non-skeletal effects have been acknowledged only in the last few years. The discovery of important vitamin D properties on the innate and adaptive immune system created a lot of interest in a potential role of vitamin D on diseases characterized by heightened inflammation and oxidative response, and impaired antimicrobial response, such as asthma and chronic obstructive pulmonary disease (COPD). Recent studies have demonstrated that vitamin D and its deficiency have a number of biological effects which are potentially important in altering the pathogenesis and severity of both asthma and COPD. Vitamin D may improve lung function and response to steroids therapy, reduce airway remodeling and disease exacerbations. The aim of this study is to review the role of Vitamin D in asthma and COPD.
维生素D是一种脂溶性维生素，可通过紫外线照射使皮肤中的7-脱氢胆固醇转化以及通过饮食获取。其对骨矿化的作用已为人所知两百多年，而其非骨骼效应直到最近几年才得到认可。维生素D对先天和适应性免疫系统具有重要特性这一发现，引发了人们对维生素D在以炎症加剧、氧化反应增强以及抗菌反应受损为特征的疾病（如哮喘和慢性阻塞性肺疾病（COPD））中潜在作用的浓厚兴趣。最近的研究表明，维生素D及其缺乏具有多种生物学效应，这些效应在改变哮喘和COPD的发病机制及严重程度方面可能具有重要意义。维生素D可能改善肺功能和对类固醇治疗的反应，减少气道重塑和疾病加重。本研究的目的是综述维生素D在哮喘和COPD中的作用。
