Welch Michael J
a University of California , School of Medicine , San Diego , CA , USA.
b Allergy & Asthma Medical Group & Research Center , San Diego , CA , USA.
Expert Opin Drug Metab Toxicol. 2016 Sep;12(9):1109-19. doi: 10.1080/17425255.2016.1209485. Epub 2016 Jul 28.
Incorrect use of inhaler devices by patients with asthma is common and can adversely affect clinical outcomes. Devices that are straightforward to use are less likely to result in dosing errors and can improve patients' satisfaction with therapy and adherence. A novel dry-powder formulation of the rescue bronchodilator albuterol (salbutamol) administered using a multidose dry-powder inhaler (mDPI; RespiClick™) has recently been approved in the USA.
Studies on the albuterol mDPI were identified in searches of PubMed and www.clinicaltrials.gov . Pharmacokinetic, pharmacodynamic, efficacy, and safety data, and patients' experiences with the albuterol mDPI are presented.
The albuterol mDPI has an efficacy/tolerability profile consistent with other inhaled forms of albuterol, and is reliable, easy to use, and associated with a high level of patient satisfaction. This is the first albuterol dry-powder inhaler (DPI) to become available in the USA, with most other formulations being delivered using a pressurized metered-dose inhaler (pMDI). The availability of a breath-actuated device avoids the challenge of coordinating actuation and breathing when using pMDIs, and could simplify treatment for patients also using a DPI for controller medication. Additional features of RespiClick, such as an integrated dose counter and minimal pre-inhalation preparation, facilitate its use.
哮喘患者不正确使用吸入装置的情况很常见，这可能会对临床结果产生不利影响。使用简便的装置导致给药错误的可能性较小，并且可以提高患者对治疗的满意度和依从性。一种使用多剂量干粉吸入器（mDPI；RespiClick™）给药的新型急救支气管扩张剂沙丁胺醇（舒喘灵）干粉制剂最近已在美国获得批准。
通过检索PubMed和www.clinicaltrials.gov确定了关于沙丁胺醇mDPI的研究。本文介绍了其药代动力学、药效学、疗效和安全性数据，以及患者使用沙丁胺醇mDPI的体验。
沙丁胺醇mDPI的疗效/耐受性与其他吸入形式的沙丁胺醇一致，可靠、易于使用，并且患者满意度高。这是美国首个上市的沙丁胺醇干粉吸入器（DPI），大多数其他制剂是通过压力定量吸入器（pMDI）给药的。呼吸驱动装置的可用性避免了使用pMDI时协调驱动和呼吸的挑战，并且可以简化同时使用DPI进行控制药物治疗的患者的治疗。RespiClick的其他功能，如集成剂量计数器和最少的吸入前准备，便于其使用。
