Voicikas Aleksandras, Niciute Ieva, Ruksenas Osvaldas, Griskova-Bulanova Inga
Department of Neurobiology and Biophysics, Vilnius University, Vilnius, Lithuania.
Department of Neurobiology and Biophysics, Vilnius University, Vilnius, Lithuania.
Neurosci Lett. 2016 Aug 26;629:215-220. doi: 10.1016/j.neulet.2016.07.019. Epub 2016 Jul 15.
Auditory steady-state responses (ASSRs) are used to test the ability of local cortical networks to generate gamma frequency activity in patients with psychiatric disorders. For the effective use of ASSRs in research and clinical applications, it is necessary to find a comfortable stimulation type and to know how ASSRs are modulated by the tasks given to the subjects during the recording session. We aimed to evaluate the suitability of flutter amplitude modulated tone (FAM) stimulation for generation of ASSRs: subjective pleasantness of FAMs and attentional effects on FAM-elicited 40Hz ASSRs were assessed. Commonly used click stimulation was used for comparison. FAMs produced ASSRs that were stable over the variety of tasks - they were not modulated by attentional demands during the task; responses to clicks were reduced and less synchronized during distraction. FAM stimuli were rated as less unpleasant and less arousing than click stimuli, thus being more pleasant to the subjects. Our findings suggest that FAM stimulation might be more suitable in conditions, where attention is difficult to control, i.e. in clinical settings.
听觉稳态反应（ASSRs）用于测试精神疾病患者局部皮质网络产生γ频率活动的能力。为了在研究和临床应用中有效使用ASSRs，有必要找到一种舒适的刺激类型，并了解在记录过程中给予受试者的任务如何调节ASSRs。我们旨在评估颤振幅度调制音（FAM）刺激产生ASSRs的适用性：评估了FAMs的主观愉悦度以及注意力对FAM诱发的40Hz ASSRs的影响。使用常用的点击刺激进行比较。FAMs产生的ASSRs在各种任务中都很稳定——它们在任务期间不受注意力需求的调节；在分心时，对点击的反应减少且同步性降低。FAM刺激被评为比点击刺激更不令人不快和更不引起兴奋，因此对受试者来说更令人愉悦。我们的研究结果表明，在难以控制注意力的情况下，即临床环境中，FAM刺激可能更合适。
