世界贸易中心健康计划一般响应者队列中哮喘和胃食管反流病发病率的性别差异。
Sex differences in asthma and gastroesophageal reflux disease incidence among the World Trade Center Health Program General Responder Cohort.
作者信息
Jiang Jieying, Icitovic Nikolina, Crane Michael A, Dasaro Christopher R, Kaplan Julia R, Lucchini Roberto G, Luft Benjamin J, Moline Jacqueline M, Pendem Lakshmi, Shapiro Moshe, Udasin Iris G, Todd Andrew C, Teitelbaum Susan L
机构信息
Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Department of Medicine, Stony Brook University Medical Center, Stony Brook, New York.
出版信息
Am J Ind Med. 2016 Sep;59(9):815-22. doi: 10.1002/ajim.22634. Epub 2016 Jul 18.
BACKGROUND
Asthma and gastroesophageal reflux disease (GERD) are two common conditions among the responders to the WTC attacks. This study examined whether the cumulative incidence rates of asthma and GERD differed by sex among 24,022 and 23,557 WTC responders, respectively.
METHODS
Cox proportional hazards regression was used to examine the sex difference in the rate of onset of physician-diagnosed asthma or GERD, from 9/12/2001 through 12/31/2015.
RESULTS
The cumulative incidence of asthma reached 23% for women and 17% for men by the end of 2015, and the cumulative incidence of GERD reached 45% for women and 38% for men. Comparing women to men, the hazard ratio was 1.48 (95% confidence interval (CI): 1.27, 1.74) for asthma, and 1.25 (95% CI: 1.13, 1.38) for GERD.
CONCLUSIONS
WTC general responders have a substantial burden of asthma and GERD, with higher incidence in women. Am. J. Ind. Med. 59:815-822, 2016. © 2016 Wiley Periodicals, Inc.
背景
哮喘和胃食管反流病（GERD）是世贸中心袭击事件受害者中的两种常见病症。本研究分别调查了24,022名和23,557名世贸中心受害者中哮喘和GERD的累积发病率是否存在性别差异。
方法
采用Cox比例风险回归分析2001年9月12日至2015年12月31日期间医生诊断的哮喘或GERD发病速率的性别差异。
结果
到2015年底，女性哮喘累积发病率达23%，男性为17%；女性GERD累积发病率达45%，男性为38%。与男性相比，女性患哮喘的风险比为1.48（95%置信区间（CI）：1.27, 1.74），患GERD的风险比为1.25（95% CI：1.13, 1.38）。
结论
世贸中心普通受害者承受着哮喘和GERD的沉重负担，女性发病率更高。《美国工业医学杂志》59:815 - 822, 2016年。© 2016威利期刊公司。
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