Luo Jing-Ying, Liu Xin, Jiang Miao, Zhao Hui-Ping, Zhao Jing-Jun
a Department of Dermatology , Shanghai Tongji Hospital, Tongji University School of Medicine , Shanghai , China.
b Department of Dermatology , Affiliated Hospital of Guilin Medical University , Guilin , Guangxi , China.
Mod Rheumatol. 2017 Mar;27(2):306-314. doi: 10.1080/14397595.2016.1206510. Epub 2016 Jul 18.
The purpose of this study is to clarify the relationship between systemic sclerosis (SSC) and oxidative stress markers in blood.
We conducted a systematic literature search of databases, including PubMed and Embase, for studies reporting circulating oxidative stress markers in patients with SSC and controls published from 1980 to December 2015. Standardized mean differences (SMDs) and 95% confidence intervals (95%CI) were calculated.
Of the 1076 articles initially retrieved, 47 were included in our meta-analysis including 12 oxidative stress markers. The concentrations of nitric oxide (SMD = 0.77; 95%CI: 0.18, 1.36; p = 0.01), malondialdehyde (SMD =1.63; 95%CI: 1.03, 2.24; p = 0.000), asymmetric dimethylarginine (SMD = 0.51; 95%CI: 0.12, 0.91; p = 0.011), and ROOH (SMD = 3.37; 95%CI: 0.28, 6.46; p = 0.033) in the blood of patients with SSC were higher than those of the control group, whereas the concentrations of superoxide dismutase (SMD = -1.11; 95%CI: -1.57, -0.65; p = 0.000) and vitamin C (SMD = -1.12; 95%CI: -1.51, -0.73; p = 0.000) were lower than in the control group.
The oxidative stress markers in blood for patients with SSC were aberrant, indicating the imbalanced states of oxidation and antioxidation in SSC.
本研究旨在阐明系统性硬化症（SSC）与血液中氧化应激标志物之间的关系。
我们对包括PubMed和Embase在内的数据库进行了系统的文献检索，以查找1980年至2015年12月发表的有关SSC患者和对照组循环氧化应激标志物的研究。计算标准化平均差（SMD）和95%置信区间（95%CI）。
在最初检索的1076篇文章中，有47篇纳入了我们的荟萃分析，涉及12种氧化应激标志物。SSC患者血液中一氧化氮（SMD = 0.77；95%CI：0.18，1.36；p = 0.01）、丙二醛（SMD = 1.63；95%CI：1.03，2.24；p = 0.000）、不对称二甲基精氨酸（SMD = 0.51；95%CI：0.12，0.91；p = 0.011）和ROOH（SMD = 3.37；95%CI：0.28，6.46；p = 0.033）的浓度高于对照组，而超氧化物歧化酶（SMD = -1.11；95%CI：-1.57，-0.65；p = 0.000）和维生素C（SMD = -1.12；95%CI：-1.51，-0.73；p = 0.000）的浓度低于对照组。
SSC患者血液中的氧化应激标志物异常，表明SSC中氧化与抗氧化状态失衡。
