Sah Jaishree, Singh Indu
Amity Institute of Pharmacy, Amity University, Noida, India.
Curr Drug Res Rev. 2025;17(1):76-89. doi: 10.2174/0125899775271616231205111827.
Fibrosis is the leading cause of many lethal diseases. It is characterized by the accumulation of extracellular matrix (ECM) components, which leads to damaged tissue functioning in the influenced organs. Essential oils are concentrated hydrophobic liquid having volatile compounds extracted from plant or plant parts while antioxidants are the compounds that help in scavenging free radicals and prevent reducing the oxidation processes. In this review, challenges that come during the treatment of fibrosis have been covered, mechanism of action of both essential oil and antioxidants is also outlined in this article. This review aimed to provide scientific fundamental and knowledge, ideas for the development and application of essential oils and antioxidants in the treatment of fibrosis.
纤维化是许多致命疾病的主要病因。其特征是细胞外基质(ECM)成分的积累,这会导致受影响器官的组织功能受损。精油是从植物或植物部分提取的具有挥发性化合物的浓缩疏水液体,而抗氧化剂是有助于清除自由基并防止氧化过程的化合物。在本综述中,涵盖了纤维化治疗过程中出现的挑战,本文还概述了精油和抗氧化剂的作用机制。本综述旨在为精油和抗氧化剂在纤维化治疗中的开发和应用提供科学基础、知识和思路。