肾皮质膜中的内肽酶-24.11对猪脑钠肽（pBNP - 26）的降解作用。
Degradation of porcine brain natriuretic peptide (pBNP-26) by endoprotease-24.11 from kidney cortical membranes.
作者信息
Vogt-Schaden M, Gagelmann M, Hock D, Herbst F, Forssmann W G
机构信息
Institut für Anatomie und Zellbiologie III, Universität Heidelberg, FRG.
出版信息
Biochem Biophys Res Commun. 1989 Jun 30;161(3):1177-83. doi: 10.1016/0006-291x(89)91366-1.
Porcine brain natriuretic peptide of 26 amino acid residues (pBNP-26) is inactivated by endoprotease-24.11 (EC 3.4.24.11) of kidney cortical membranes. In contrast to human alpha atrial natriuretic peptide/cardiodilatin (ANP/CDD) showing a single major cleavage within the disulfide-linked loop between Cys and Phe in position 7 and 8, pBNP-26 is cleaved at several sites. Although both pBNP-26 and ANP/CDD exhibit Cys-Phe peptide bonds at the corresponding positions this bond is not cleaved in BNP-26.
由26个氨基酸残基组成的猪脑钠肽（pBNP - 26）会被肾皮质膜中的内肽酶 - 24.11（EC 3.4.24.11）灭活。与人类α - 心房钠尿肽/心钠素（ANP/CDD）在第7位和第8位的半胱氨酸（Cys）和苯丙氨酸（Phe）之间的二硫键连接环内有一个主要切割位点不同，pBNP - 26在多个位点被切割。尽管pBNP - 26和ANP/CDD在相应位置都有Cys - Phe肽键，但该键在BNP - 26中不会被切割。
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