与心钠素/心钠素（α-hANP/CDD-99-126）不同，尿舒张素（CDD/ANP-95-126）不会被犬肾皮质膜中的肽酶进行生物失活。
Urodilatin (CDD/ANP-95-126) is not biologically inactivated by a peptidase from dog kidney cortex membranes in contrast to atrial natriuretic peptide/cardiodilatin (alpha-hANP/CDD-99-126).
作者信息
Gagelmann M, Hock D, Forssmann W G
机构信息
Institute of Anatomy and Cell Biology, University of Heidelberg, FRG.
出版信息
FEBS Lett. 1988 Jun 20;233(2):249-54. doi: 10.1016/0014-5793(88)80436-8.
Atrial natriuretic peptide (CDD/ANP-99-126) is rapidly inactivated by a membrane preparations from dog kidney cortex. Inactivation occurs by cleavage of the ring structure in the position between Cys-105 and Phe-106. A unique proteolytic product separated by HPLC on reverse-phase column appears as a single peak which elutes prior the intact peptide. In contrast, CDD/ANP-95-126 (urodilatin) which is released from the kidney is not destroyed by proteolysis using an identical membrane preparation.
心房利钠肽（CDD/ANP-99-126）可被犬肾皮质的膜制剂迅速灭活。灭活是通过在半胱氨酸-105和苯丙氨酸-106之间的位置切割环结构来实现的。通过反相柱上的高效液相色谱分离出的一种独特的蛋白水解产物呈现为一个单峰，其洗脱时间早于完整肽段。相比之下，从肾脏释放的CDD/ANP-95-126（尿钠素）使用相同的膜制剂进行蛋白水解时不会被破坏。
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