Arbatskiĭ N P, Martynova M D, Aleshkin V A, Derevitskaia V A
Bioorg Khim. 1989 Feb;15(2):175-80.
A comparative analysis of carbohydrate chains from human normal IgG and myeloma IgG (subclass 4) was carried out using HPLC. It is shown that both IgGs contain the same carbohydrate chains (biantennary and bisected) but the relative amount of bisected and incomplete chains (with fewer terminal galactose residues) is higher in myeloma IgG4. Two earlier unknown minor oligosaccharides were isolated from normal IgG and structurally studied by means of the partial hydrolysis and the Smith degradation.
利用高效液相色谱法对人正常IgG和骨髓瘤IgG（4亚类）的糖链进行了比较分析。结果表明，两种IgG都含有相同的糖链（双触角和双分支），但骨髓瘤IgG4中双分支和不完全糖链（末端半乳糖残基较少）的相对含量更高。从正常IgG中分离出两种先前未知的次要寡糖，并通过部分水解和史密斯降解对其结构进行了研究。
