Bachert C, Keilmann A, Ganzer U
Hals-Nasen-Ohren-Klinik, Klinikum Mannheim der Universität Heidelberg.
Laryngorhinootologie. 1989 Apr;68(4):201-3. doi: 10.1055/s-2007-998317.
Besides mechanical or infectious factors in the genesis of secretory otitis media IgE-mediated hypersensitivity has often been discussed. In order to estimate the importance of an allergic reaction in the development of middle ear disease, we examined 27 children having adenoids and a secretory otitis media. We documented the patients' history of allergy and determined the IgE-levels in the serum, the middle ear effusions and the adenoid tissue. 5 out of 27 children suffered from an allergy of the upper respiratory tract, but only in one child we found an elevated level of IgE in middle ear effusion. On the basis of our investigations and recent literature, we suggest that an allergic rhinitis might cause an Eustachian tube dysfunction in a few patients. There is no evidence of a local allergic reaction of the middle ear mucosa.
除了分泌性中耳炎发病机制中的机械性或感染性因素外，IgE介导的超敏反应也经常被讨论。为了评估过敏反应在中耳疾病发展中的重要性，我们检查了27名患有腺样体和分泌性中耳炎的儿童。我们记录了患者的过敏史，并测定了血清、中耳积液和腺样体组织中的IgE水平。27名儿童中有5名患有上呼吸道过敏，但仅在1名儿童的中耳积液中发现IgE水平升高。根据我们的研究和近期文献，我们认为变应性鼻炎可能在少数患者中导致咽鼓管功能障碍。没有证据表明中耳黏膜存在局部过敏反应。
