心脏年轻化“迷宫”中的“促年轻化”因素。

"Pro-youthful" factors in the "labyrinth" of cardiac rejuvenation.

作者信息

Rochette Luc, Vergely Catherine

机构信息

Laboratoire de Physiopathologie et Pharmacologies Cardio-Métaboliques (LPPCM), INSERM UMR866, Université de Bourgogne Franche-Comté, Facultés des Sciences de Santé, 7 Boulevard Jeanne d'Arc, 21033 Dijon Cedex, France.

出版信息

Exp Gerontol. 2016 Oct;83:1-5. doi: 10.1016/j.exger.2016.07.004. Epub 2016 Jul 15.

DOI:10.1016/j.exger.2016.07.004

PMID:27426744

Abstract

The mechanisms of aging and senescence include various endogenous and exogenous factors. Among cardiovascular diseases, heart failure is a typical age-related disease. New strategies to restore cardiomyocyte cells have been reported: endogenous substances that can regenerate the heart's cardiomyocytes have been described: follistatin like 1 (FSTL1), growth-differentiation factor 11 (GDF11) and insulin-like growth factor 1 (IGF-I). Manipulation of the different anti and pro- pathways is essential to discover new approaches to regenerative therapies.

摘要

衰老和老化的机制包括各种内源性和外源性因素。在心血管疾病中，心力衰竭是一种典型的与年龄相关的疾病。已经报道了恢复心肌细胞的新策略：已经描述了可以使心脏心肌细胞再生的内源性物质：卵泡抑素样1（FSTL1）、生长分化因子11（GDF11）和胰岛素样生长因子1（IGF-I）。操纵不同的抗和促途径对于发现再生疗法的新方法至关重要。