Equipe d'Accueil (EA 7460), Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Université de Bourgogne-Franche Comté, Faculté des Sciences de Santé, 7 Bd Jeanne d'Arc, 21000 Dijon, France.
Institut de Formation en Biotechnologie et Ingénierie Biomédicale (IFR2B), Université Mohammed VI Polytechnique, 43 150 Ben-Guerir, Morocco.
Int J Mol Sci. 2019 Jul 21;20(14):3563. doi: 10.3390/ijms20143563.
In the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose levels are elevated in young animals, have been identified. The blood concentrations of these factors appear to be inversely correlated with the age-related decline of neurogenesis. The identification of GDF11 as a "rejuvenating factor" opens up perspectives for the treatment of neurodegenerative diseases. As a pro-neurogenic and pro-angiogenic agent, GDF11 may constitute a basis for novel therapeutic strategies.
在大脑中，衰老伴随着细胞和功能的缺陷，从而导致易患神经退行性疾病。在来自年轻和年老动物的血浆中，已经鉴定出各种因子，如生长分化因子 11（GDF11），其在年轻动物中的水平升高。这些因子的血液浓度似乎与神经发生的与年龄相关的下降呈负相关。将 GDF11 鉴定为“返老还童因子”为治疗神经退行性疾病开辟了前景。作为一种促神经发生和促血管生成的试剂，GDF11 可能构成新的治疗策略的基础。
