Zhang Yang, Zong Wei, Zhang Lei, Ma Yuanye, Wang Jianhong
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; Shandong Association for Science & Technology, China.
Honghe Health Vocational College, Yunnan, China.
Neurochem Int. 2016 Oct;99:215-220. doi: 10.1016/j.neuint.2016.07.007. Epub 2016 Jul 15.
Although various molecules have been found to mediate the processes of memory acquisition and consolidation, the molecular mechanism to maintain memory still remains elusive. In recent years, a molecular pathway focusing on protein kinase Mζ (PKMζ) has become of interest to researchers because of its potential role in long-term memory maintenance. PKMζ is an isoform of protein kinase C (PKC) and has a related structure that influences its function in maintaining memory. Considerable evidence has been gathered on PKMζ activity, including loss of function studies using PKMζ inhibitors, such as PKMζ inhibitory peptide (ZIP), suggesting PKMζ plays an important role in long-term memory maintenance. This review provides an overview of the role of PKMζ in long-term memory and outlines the molecular structure of PKMζ, the molecular mechanism of PKMζ in long-term memory maintenance and future directions of PKMζ research.
尽管已发现多种分子介导记忆获取和巩固过程，但维持记忆的分子机制仍不清楚。近年来，一条聚焦于蛋白激酶Mζ（PKMζ）的分子途径因其在长期记忆维持中的潜在作用而受到研究人员关注。PKMζ是蛋白激酶C（PKC）的一种同工型，具有影响其维持记忆功能的相关结构。关于PKMζ活性已积累了大量证据，包括使用PKMζ抑制剂（如PKMζ抑制肽，ZIP）进行的功能丧失研究，表明PKMζ在长期记忆维持中起重要作用。本综述概述了PKMζ在长期记忆中的作用，概述了PKMζ的分子结构、PKMζ在长期记忆维持中的分子机制以及PKMζ研究的未来方向。
