Macharia Daniel K, Yu Nuo, Zhong Runzhi, Xiao Zhiyin, Yang Jianmao, Chen Zhigang
J Nanosci Nanotechnol. 2016 Jun;16(6):5865-8. doi: 10.1166/jnn.2016.11747.
A prerequisite for the development of photothermal ablation therapy for cancer is to obtain efficient photothermal nanoagents that can be irradiated by near-infrared (NIR) laser. Herein, we have reported the synthesis of WS2 nanowires as photothermal nanoagents by the reaction of WCl6 with CS2 in oleylamine at 280 degrees C. WS2 nanowires have the thickness of -2 nm and length of -100 nm. Importantly, the chloroform dispersion of WS2 nanowires exhibits strong photoabsorption in NIR region. The temperature of the dispersion (0.10-0.50 mg/mL) can increase by 12.8-23.9 degrees C in 5 min under the irradiation of 808 nm laser with a power density of 0.80 W/cm2. Therefore, WS2 nanowires have a great superiority as a new nanoagent for NIR-induced photothermal ablation of cancer, due to their small size and excellent photothermal performance.
癌症光热消融疗法发展的一个先决条件是获得能够被近红外（NIR）激光照射的高效光热纳米剂。在此，我们报道了通过WCl6与CS2在油胺中于280℃反应合成作为光热纳米剂的WS2纳米线。WS2纳米线的厚度约为2nm，长度约为100nm。重要的是，WS2纳米线的氯仿分散体在近红外区域表现出强烈的光吸收。在功率密度为0.80W/cm2的808nm激光照射下，分散体（0.10 - 0.50mg/mL）的温度在5分钟内可升高12.8 - 23.9℃。因此，WS2纳米线由于其尺寸小和优异的光热性能，作为一种用于近红外诱导癌症光热消融的新型纳米剂具有很大的优势。
