免疫功能正常患者中仅累及骨骼、酷似骨肉瘤的浆母细胞淋巴瘤：一例报告
Plasmablastic lymphoma exclusively involving bones mimicking osteosarcoma in an immunocompetent patient: A case report.
作者信息
Sarker Azmal Kabir, Im Hyung-Jun, Paeng Jin Chul, Cheon Gi Jeong, Kang Keon Wook, Chung June-Key, Lee Dong Soo
机构信息
Department of Nuclear Medicine Fellowship of Koh Chang Soon Program, Seoul National University College of Medicine, Seoul, Korea National Institute of Nuclear Medicine and Allied Sciences, BAEC, BSMMU campus, Dhaka, Bangladesh Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea.
出版信息
Medicine (Baltimore). 2016 Jul;95(28):e4241. doi: 10.1097/MD.0000000000004241.
BACKGROUND
It has been known that plasmablastic lymphoma (PBL) is a neoplasm of immunocompromised patients occurring in soft tissue of oral cavity or in the vicinity whereas bone is an unlikely site to harbor PBL. However, its occurrence is increasingly being reported in immunocompetent individuals in either osseous or extra-oral sites. To our best knowledge, F-18 FDG PET/CT findings of PBL involving bones in an immunocompetent patient have not been reported, yet .
CASE SUMMARY
We report a case of PBL involving multiple bones in an immunocompetent patient. Features of different imaging modalities including F-18 Fluoro-deoxy glucose (FDG) positron emission tomography/computed tomography (PET/CT) were correlated well as findings of osteosarcoma in mandible with metastatic lesions. However, the histopathology and immunohistochemistry (IHC) of bone tissues from 2 separate biopsy sites revealed features of PBL.
CONCLUSION
awareness to F-18 FDG PET/CT findings of PBL involving bones in an immunocompetent patient may prevent misdiagnosis.
背景
已知浆母细胞淋巴瘤（PBL）是免疫功能低下患者发生于口腔软组织或其附近的一种肿瘤，而骨骼是不太可能发生PBL的部位。然而，其在免疫功能正常个体的骨内或口腔外部位的发生报道日益增多。据我们所知，免疫功能正常患者发生的累及骨骼的PBL的F-18 FDG PET/CT表现尚未见报道。
病例摘要
我们报告1例免疫功能正常患者发生的累及多骨的PBL。不同影像学检查方法的特征，包括F-18氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT），与下颌骨骨肉瘤伴转移灶的表现密切相关。然而，来自2个不同活检部位的骨组织的组织病理学和免疫组织化学（IHC）显示为PBL特征。
结论
认识免疫功能正常患者发生的累及骨骼的PBL的F-18 FDG PET/CT表现可能有助于防止误诊。
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