骨转移诊断：¹⁸FDG PET、CT、MRI 和骨闪烁显像比较的荟萃分析。
Diagnosis of bone metastases: a meta-analysis comparing ¹⁸FDG PET, CT, MRI and bone scintigraphy.
机构信息
Department of Orthopaedics, The first affiliated hospital of Soochow University, No188, Shizi Street, Suzhou 215006, People's Republic of China.
出版信息
Eur Radiol. 2011 Dec;21(12):2604-17. doi: 10.1007/s00330-011-2221-4. Epub 2011 Sep 2.
OBJECTIVE
To perform a meta-analysis to compare (18)FDG PET, CT, MRI and bone scintigraphy (BS) for the diagnosis of bone metastases.
METHODS
Databases including MEDLINE and EMBASE were searched for relevant original articles published from January 1995 to January 2010. Software was used to obtain pooled estimates of sensitivity, specificity and summary receiver operating characteristic curves (SROC).
RESULTS
67 articles consisting of 145 studies fulfilled all inclusion criteria. On per-patient basis, the pooled sensitivity estimates for PET, CT, MRI and BS were 89.7%, 72.9%, 90.6% and 86.0% respectively. PET=MRI>BS>CT. ("="indicated no significant difference, P > 0.05; ">" indicated significantly higher, P < 0.05). The pooled specificity estimates for PET, CT, MRI and BS were 96.8%, 94.8%, 95.4% and 81.4% respectively. PET = CT = MRI>BS. On per-lesion basis, the pooled sensitivity estimates for PET, CT, MRI and BS were 86.9%, 77.1%, 90.4% and 75.1% respectively. PET = MRI>BS>CT. The pooled specificity estimates for PET, CT, MRI and BS were 97.0%, 83.2%, 96.0% and 93.6% respectively. PET>MRI>BS>CT.
CONCLUSION
PET and MRI were found to be comparable and both significantly more accurate than CT and BS for the diagnosis of bone metastases.
目的
进行荟萃分析以比较（18）FDG PET、CT、MRI 和骨闪烁扫描（BS）在诊断骨转移中的作用。
方法
检索 MEDLINE 和 EMBASE 数据库，以获取 1995 年 1 月至 2010 年 1 月发表的相关原始文章。使用软件获取汇总的敏感性、特异性和综合受试者工作特征曲线（SROC）估计值。
结果
67 篇文章（包含 145 项研究）符合所有纳入标准。基于每位患者，PET、CT、MRI 和 BS 的汇总敏感性估计值分别为 89.7%、72.9%、90.6%和 86.0%。PET=MRI>BS>CT。（“=”表示无显著差异，P>0.05；“>”表示显著更高，P<0.05）。PET、CT、MRI 和 BS 的汇总特异性估计值分别为 96.8%、94.8%、95.4%和 81.4%。PET=CT=MRI>BS。基于每个病变，PET、CT、MRI 和 BS 的汇总敏感性估计值分别为 86.9%、77.1%、90.4%和 75.1%。PET=MRI>BS>CT。PET、CT、MRI 和 BS 的汇总特异性估计值分别为 97.0%、83.2%、96.0%和 93.6%。PET>MRI>BS>CT。
结论
与 CT 和 BS 相比，PET 和 MRI 被发现对于诊断骨转移具有可比性，并且准确性更高。
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