Ministry of Education Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Hohai University, Nanjing 210098, PR China; College of Environment, Hohai University, Nanjing 210098, PR China.
Ministry of Education Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Hohai University, Nanjing 210098, PR China; College of Environment, Hohai University, Nanjing 210098, PR China.
Ecotoxicol Environ Saf. 2016 Nov;133:97-104. doi: 10.1016/j.ecoenv.2016.06.047. Epub 2016 Jul 16.
Dichloroacetonitrile (DCAN) is a typical nitrogenous disinfection by-product (N-DBP) and its toxicity on aquatic animals is investigated for the first time. The present study was designed to investigate the potential adverse effects of DCAN on zebrafish. DCAN could induce developmental toxicity to zebrafish embryos. A significant decrease in hatchability and an increase in malformation and mortality occurred when DCAN concentration was above 100µg/L. Heart function alteration and neuronal function disturbance occurred at concentration higher than 500 and 100µg/L, respectively. Further, DCAN was easily accumulated in adult zebrafish. The rank order of declining bioconcentration factor (BCF) was liver (1240-1670)> gill (1210-1430)> muscle (644-877). DCAN caused acute metabolism damage to adult zebrafish especially at 8 days exposure, at which time the "Integrated Biomarker Response" (IBR) index value reached 798 at 1mg/L DCAN dose. Acute DNA damage was induced to adult zebrafish by DCAN even at 10µg/L dose.
二氯乙腈（DCAN）是一种典型的含氮消毒副产物（N-DBP），其对水生动物的毒性尚属首次研究。本研究旨在探讨 DCAN 对斑马鱼的潜在不良影响。DCAN 可诱导斑马鱼胚胎发育毒性。当 DCAN 浓度高于 100μg/L 时，孵化率显著降低，畸形率和死亡率增加。当浓度高于 500μg/L 和 100μg/L 时，分别会出现心脏功能改变和神经元功能障碍。此外，DCAN 很容易在成年斑马鱼体内蓄积。生物浓缩系数（BCF）的递减顺序为肝脏（1240-1670）>鳃（1210-1430）>肌肉（644-877）。DCAN 对成年斑马鱼造成急性代谢损伤，尤其是在 8 天暴露时，1mg/L DCAN 剂量下的“综合生物标志物反应”（IBR）指数值达到 798。即使在 10μg/L 剂量下，DCAN 也会引起成年斑马鱼的急性 DNA 损伤。
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