College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing and, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, P. R. China.
School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, P. R. China.
Chem Asian J. 2016 Sep 6;11(17):2458-69. doi: 10.1002/asia.201600920. Epub 2016 Aug 12.
The versatile application of nanoparticles in integrating imaging and therapy has aroused extensive research interest in precision medicine. Of the various nanoparticles that have been studied, CuS has shown great potential in the construction of multifunctional agents, owing to its excellent photothermal heating properties. Herein, we report a facile one-pot biomineralization approach for the preparation of versatile bovine-serum-albumin-conjugated CuS/Gd2 O3 hybrid nanoparticles (BSA-CuS/Gd2 O3 HNPs), which simultaneously possessed strong longitudinal relaxivity, an outstanding photothermal effect, high drug-loading capacity, and pH/temperature-responsive drug release. The versatile nanoparticles were used for magnetic resonance imaging (MRI) and antitumor photothermal chemotherapy, both in vitro and in vivo. In vivo MRI showed that the BSA-CuS/Gd2 O3 HNPs had a long circulation time and effective passive tumor-uptake ability. More importantly, combined in vitro and in vivo therapy demonstrated that drug-loaded BSA-CuS/Gd2 O3 HNPs offered outstanding synergistic therapeutic efficacy for tumor inhibition.
多功能纳米粒子在整合成像和治疗中的应用在精准医学领域引起了广泛的研究兴趣。在已经研究过的各种纳米粒子中，CuS 因其优异的光热加热性能，在构建多功能试剂方面显示出巨大的潜力。在此，我们报告了一种简便的一锅生物矿化方法，用于制备多功能牛血清白蛋白偶联的 CuS/Gd2 O3 杂化纳米粒子（BSA-CuS/Gd2 O3 HNPs），其同时具有强纵向弛豫率、优异的光热效应、高载药能力以及 pH/温度响应性药物释放。多功能纳米粒子用于体外和体内磁共振成像（MRI）和抗肿瘤光热化疗。体内 MRI 表明 BSA-CuS/Gd2 O3 HNPs 具有较长的循环时间和有效的被动肿瘤摄取能力。更重要的是，体外和体内联合治疗表明，负载药物的 BSA-CuS/Gd2 O3 HNPs 为肿瘤抑制提供了出色的协同治疗效果。
