Chou Hui-Ting, Dukovski Danijela, Chambers Melissa G, Reinisch Karin M, Walz Thomas
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, USA.
Nat Struct Mol Biol. 2016 Aug;23(8):761-3. doi: 10.1038/nsmb.3264. Epub 2016 Jul 18.
We show here that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same subunit organization. We also show that HOPS, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, thus suggesting that multisubunit tethering complexes use related structural frameworks.
我们在此表明，酿酒酵母GARP复合物以及COG复合物的Cog1 - 4亚复合物，这两个与含螺旋杆系链复合物（CATCHR）家族相关的多亚基系链复合物成员，具有相同的亚基组织。我们还表明，在内溶酶体途径中起作用的系链复合物HOPS具有相似的结构，因此表明多亚基系链复合物使用相关的结构框架。
