完整的COG拴系复合体的分子结构
Molecular architecture of the complete COG tethering complex.
作者信息
Ha Jun Yong, Chou Hui-Ting, Ungar Daniel, Yip Calvin K, Walz Thomas, Hughson Frederick M
机构信息
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Nat Struct Mol Biol. 2016 Aug;23(8):758-60. doi: 10.1038/nsmb.3263. Epub 2016 Jul 18.
The conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG complex from Saccharomyces cerevisiae. Intact COG has an intricate shape, with four (or possibly five) flexible legs, that differs strikingly from that of the exocyst complex and appears to be well suited for vesicle capture and fusion.
保守寡聚高尔基体（COG）复合体协调囊泡向高尔基体的运输以及在高尔基体内部的运输。在此，我们使用负染电子显微镜来阐明酿酒酵母异源八聚体COG复合体的结构。完整的COG具有复杂的形状，有四条（或可能五条）灵活的“腿”，这与外泌体复合体的形状显著不同，似乎非常适合囊泡的捕获和融合。
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