精神疾病、发病率和死亡率：探寻加速衰老的机制途径
Psychiatric Disorders, Morbidity, and Mortality: Tracing Mechanistic Pathways to Accelerated Aging.
作者信息
Kiecolt-Glaser Janice K, Wilson Stephanie J
机构信息
From the Ohio State Institute for Behavioral Medicine Research (Kiecolt-Glaser and Wilson) and the Department of Psychiatry and Behavioral Health (Kiecolt-Glaser), The Ohio State University College of Medicine, Columbus, Ohio.
出版信息
Psychosom Med. 2016 Sep;78(7):772-5. doi: 10.1097/PSY.0000000000000373.
Abstract
A meta-analysis published in this issue of Psychosomatic Medicine provides convincing evidence that certain psychiatric populations have shorter telomeres than nonpsychiatric controls, in accord with the strong evidence linking psychiatric disorders with premature mortality. After addressing the clinical significance of shorter telomeres, this editorial describes mechanistic pathways that lead to telomere shortening. Additionally, two other novel methods for measuring biological markers of accelerated aging are briefly discussed: DNA methylation and cellular senescence based on p16. These innovative approaches could be used to confirm and extend our understanding of psychiatric patients' increased health and mortality risks.
摘要
发表在本期《身心医学》上的一项荟萃分析提供了令人信服的证据，表明某些精神疾病患者的端粒比非精神疾病对照者短，这与将精神疾病与过早死亡联系起来的有力证据一致。在阐述了较短端粒的临床意义后，这篇社论描述了导致端粒缩短的机制途径。此外，还简要讨论了另外两种测量加速衰老生物标志物的新方法：DNA甲基化和基于p16的细胞衰老。这些创新方法可用于证实和扩展我们对精神疾病患者健康和死亡风险增加的理解。
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