Alcántara-Garcés María Teresa, Rodríguez-Ramírez Alejandra Monserrat, García-Ulloa Ana Cristina, Hernández-Jiménez Sergio
Centro de Atención Integral del Paciente con Diabetes (CAIPaDi), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Neuropsychiatr Dis Treat. 2022 Jun 12;18:1151-1163. doi: 10.2147/NDT.S364556. eCollection 2022.
To describe the metabolic status and clinical characteristics associated with NPPD in patients with less than five years of T2D diagnosis and explore the role of age in the presentation of psychiatric comorbidities.
This was a cross-sectional study of subjects who attended a comprehensive care program. Patients were assessed using the Mini-International Neuropsychiatric Interview, and clinical and metabolic characteristics were registered. Multivariate logistic regression analyses were conducted to identify risk and protective factors for psychiatric disorders. We performed an analysis to further explore age's influence on our results.
We included 1953 patients, and 40.1% had any psychiatric disorder. Younger age, female sex, and personal psychiatric history were associated with NPPD. The use of insulin was reported as a protective factor for eating disorders. Body mass index was associated with any psychiatric disorders and eating disorders. The analysis of age reported that patients younger than 45 years had the worst metabolic parameters and increased odds for NPPD, while patients older than 65 years had the best metabolic measures and decreased odds for psychiatric comorbidity.
NPPD were frequent comorbidities in our sample; younger age, female sex, and personal psychiatric history were the most important factors associated with psychiatric comorbidities. Younger subjects experience a higher risk for psychiatric disorders and worst metabolic control.
描述糖尿病诊断年限不足5年的2型糖尿病患者中与非糖尿病性精神障碍（NPPD）相关的代谢状况和临床特征，并探讨年龄在精神共病表现中的作用。
这是一项对参加综合护理项目的受试者进行的横断面研究。使用《迷你国际神经精神访谈》对患者进行评估，并记录临床和代谢特征。进行多因素逻辑回归分析以确定精神障碍的风险和保护因素。我们进行了一项分析以进一步探讨年龄对我们结果的影响。
我们纳入了1953例患者，40.1%的患者患有任何精神障碍。年龄较小、女性以及有个人精神病史与NPPD相关。胰岛素的使用被报告为饮食失调的保护因素。体重指数与任何精神障碍和饮食失调相关。年龄分析表明，45岁以下的患者代谢参数最差，患NPPD的几率增加，而65岁以上的患者代谢指标最佳，精神共病的几率降低。
在我们的样本中，NPPD是常见的共病；年龄较小、女性以及有个人精神病史是与精神共病相关的最重要因素。较年轻的受试者患精神障碍的风险更高，代谢控制更差。
