Andreeva L A, Bakaneva V F, Grigorenko E V, Kondrashova M N
Biofizika. 1989 Mar-Apr;34(2):306-9.
It is shown that negative hydroaeroions cause a decrease of the systole strength of freshly prepared auricle and activation of the tired auricle; a decrease of the amplitude and length of the heart trabecula action potentials due to depression of slow input Ca2+ current; shift of the threshold of activation of fast input Na+ current to low potentials; partly elimination of the rise of the auricle systole strength under novodrine. The latter effects were not observed under atropine and indomethacin.
结果表明,负性氢氧离子可导致新制备的心房收缩强度降低,使疲劳的心房激活;由于慢内向Ca2+电流受抑制,导致心脏小梁动作电位的幅度和时长减小;快内向Na+电流的激活阈值向低电位偏移;部分消除了新福林作用下的心房收缩强度增加。在阿托品和消炎痛作用下未观察到后一种效应。