Filippov A K, Skatova G E, Porotikov V I, Orlov B N, Asafova N N
Biofizika. 1987 Jul-Aug;32(4):620-3.
It has been shown on auricle fibres of the frog that neurotoxin from bee poison melittin suppresses the ionic currents entering the cell through calcium and sodium channels of the membrane, increases the background potassium current, suppresses phasic and tonic contraction of the fibres. Toxin modifies the kinetics of calcium channels, but does not affect activation and desensitization of beta adrenoreceptors. Effects of melittin are not decreased when adding the inhibitor of phospholipase A2 indomethacin. The results show that melittin directly affects the protein components of the membrane-ionic channels, probably binding with them.
业已表明，在青蛙的耳廓纤维上，蜂毒中的神经毒素蜂毒肽可抑制通过细胞膜钙通道和钠通道进入细胞的离子电流，增加背景钾电流，抑制纤维的相位性和强直性收缩。该毒素可改变钙通道的动力学，但不影响β肾上腺素能受体的激活和脱敏。添加磷脂酶A2抑制剂吲哚美辛时，蜂毒肽的作用不会减弱。结果表明，蜂毒肽直接影响膜离子通道的蛋白质成分，可能与其结合。
